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S-Phase Kinase-Associated Protein 2 (SKP2) Antibody
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Catalogue No: abx011527
Price:
US$427.75
(Size: 100 µl)
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SKP2: S-phase kinase-associated protein 2 (p45). This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms.
Research Articles on S-Phase Kinase-Associated Protein 2 (SKP2)
| Target | S-Phase Kinase-Associated Protein 2 (SKP2) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of SKP2 (aa1-130) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13309 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K5E0, B4DJT4, Q8TDZ0, Q8TDZ1, Q9BV69 |
| UniProt Entry Name | SKP2_HUMAN |
| Gene Symbol | SKP2 |
| GeneID | 6502 |
| OMIM | 601436 |
| HGNC | 10901 |
| KEGG | hsa:6502 |
| Ensembl | ENSG00000145604 |
| String | 9606.ENSP00000274255 |
| Molecular Weight | 47 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |