Sodium/Calcium Exchanger 1 (SLC8A1) Antibody

In cardiac myocytes, Ca (2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca (2+) centration during contraction is primarily due to release of Ca (2+) from intracellular stores. However, some Ca (2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca (2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca (2+) that entered across the sarcolemma must be extruded from the cell. The Na (+) Ca (2+) exchanger is the primary mechanism by which the Ca (2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.

Target	Sodium/Calcium Exchanger 1 (SLC8A1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 296-325 amino acids from the Central region of human SLC8A1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P32418 (UniProt, ExPASy)
UniProt Entry Name	NAC1_HUMAN
Gene Symbol	SLC8A1
NCBI Accession	NP_001106271.1 NP_001106272.1 NP_001106273.1 NP_001239553.1 NP_066920.1
KEGG	hsa:6546
String	9606.ENSP00000384763
Molecular Weight	Calculated MW: 109 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat and Cow SLC8A1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Sodium/Calcium Exchanger 1 (SLC8A1)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue