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Mothers Against Decapentaplegic Homolog 2 (SMAD2) Antibody
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Catalogue No: abx033353
Price:
US$290.00
(Size: 80 µl)
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The protein belongs to the SMAD, a family of proteins similar to the proteins of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF) beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin.
Research Articles on Mothers Against Decapentaplegic Homolog 2 (SMAD2)
| Target | Mothers Against Decapentaplegic Homolog 2 (SMAD2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IF/ICC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IF/ICC: 1/100, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 97-125 amino acids from human SMAD2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q15796 (UniProt, ExPASy) |
| UniProt Entry Name | SMAD2_HUMAN |
| KEGG | hsa:4087 |
| String | 9606.ENSP00000262160 |
| Molecular Weight | Calculated MW: 52.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat, Cow, Pig, Zebrafish and Drosophila SMAD2. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |