Structural Maintenance of Chromosomes 1A (SMC1A) Antibody

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq].

Target	Structural Maintenance of Chromosomes 1A (SMC1A)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 307-336 amino acids from the N-terminal region of human SMC1A.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14683 (UniProt, ExPASy)
UniProt Secondary AC	O14995, Q16351, Q2M228
UniProt Entry Name	SMC1A_HUMAN
KEGG	hsa:8243
String	9606.ENSP00000323421
Molecular Weight	Calculated MW: 143 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Cow SMC1A.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Structural Maintenance of Chromosomes 1A (SMC1A)

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