Structural Maintenance of Chromosomes Protein 3 (SMC3) Antibody

This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.

Target	Structural Maintenance of Chromosomes Protein 3 (SMC3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 402-430 amino acids from the Central region of human SMC3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UQE7 (UniProt, ExPASy)
UniProt Secondary AC	A8K156, O60464, Q5T482
UniProt Entry Name	SMC3_HUMAN
Gene Symbol	SMC3
String	9606.ENSP00000354720
Molecular Weight	Calculated MW: 142 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Cow SMC3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Structural Maintenance of Chromosomes Protein 3 (SMC3)

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