Snail Family Transcriptional Repressor 2 / SLUG (SNAI2) Antibody

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Catalogue No: abx117024
Price: US$478.50
(Size: 100 µl)
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Snail Family Transcriptional Repressor 2 / SLUG (SNAI2) Antibody

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Datasheet SDS
SNAI2 Antibody is a Rabbit Polyclonal antibody against SNAI2. Slug (SNAI2) is a widely expressed transcriptional repressor and member of the Snail family of zinc finger transcription factorsSimilar to the related Snail protein, Slug binds to the E-cadherin promoter region to repress transcription during developmentThe binding of Slug to integrin promoter sequences represses integrin expression and results in reduced cell adhesionDown regulation of E-cadherin expression occurs during the epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cellsThe tumor suppressor protein p53 induces Slug expression in γ-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein PumaDeletion mutations in the corresponding Slug gene are associated with the pigmentation disorders Waardenburg Syndrome and Piebaldism, while a genetic duplication resulting in Slug overexpression is associated with a collection of congenital heart defects termed tetralogy of Fallot.

Target Snail Family Transcriptional Repressor 2 / SLUG (SNAI2)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human SNAI2.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O43623 (UniProt, ExPASy)
UniProt Secondary AC B2R6P6, Q53FC1
UniProt Entry Name SNAI2_HUMAN
Gene Symbol SNAI2
GeneID 6591
KEGG hsa:6591
String 9606.ENSP00000380034
Buffer PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Snail Family Transcriptional Repressor 2 / SLUG (SNAI2)
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