+44 (0) 1223 755950
+1 832 327 7413
Snail Family Transcriptional Repressor 2 / SLUG (SNAI2) Antibody
REQUEST MORE INFO
Catalogue No: abx117024
Price:
US$522.00
(Size: 100 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
SNAI2 Antibody is a Rabbit Polyclonal antibody against SNAI2. Slug (SNAI2) is a widely expressed transcriptional repressor and member of the Snail family of zinc finger transcription factorsSimilar to the related Snail protein, Slug binds to the E-cadherin promoter region to repress transcription during developmentThe binding of Slug to integrin promoter sequences represses integrin expression and results in reduced cell adhesionDown regulation of E-cadherin expression occurs during the epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cellsThe tumor suppressor protein p53 induces Slug expression in γ-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein PumaDeletion mutations in the corresponding Slug gene are associated with the pigmentation disorders Waardenburg Syndrome and Piebaldism, while a genetic duplication resulting in Slug overexpression is associated with a collection of congenital heart defects termed tetralogy of Fallot.
Research Articles on Snail Family Transcriptional Repressor 2 / SLUG (SNAI2)
| Target | Snail Family Transcriptional Repressor 2 / SLUG (SNAI2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein of human SNAI2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O43623 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R6P6, Q53FC1 |
| UniProt Entry Name | SNAI2_HUMAN |
| Gene Symbol | SNAI2 |
| GeneID | 6591 |
| KEGG | hsa:6591 |
| String | 9606.ENSP00000380034 |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |