+44 (0) 1223 755950
+1 832 327 7413
Suppressor of Cytokine Signaling 1 (SOCS-1) Antibody
REQUEST MORE INFO
Catalogue No: abx218825
Price:
US$406.00
(Size: 100 µg)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
Suppressor of Cytokine Signaling 1 (SOCS-1) Antibody is a Rabbit Polyclonal antibody for the detection of SOCS1. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN) -gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Research Articles on Suppressor of Cytokine Signaling 1 (SOCS-1)
| Target | Suppressor of Cytokine Signaling 1 (SOCS-1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Suppressor of cytokine signaling 1 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | O15524 (UniProt, ExPASy) |
| UniProt Secondary AC | O15097, Q9NSA7 |
| UniProt Entry Name | SOCS1_HUMAN |
| Gene Symbol | SOCS1 |
| GeneID | 8651 |
| OMIM | 603597 |
| HGNC | 19383 |
| KEGG | hsa:8651 |
| Ensembl | ENSG00000185338 |
| String | 9606.ENSP00000329418 |
| Molecular Weight | Observed MW: 24 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |