Sorbitol Dehydrogenase (SORD) Antibody

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD (+) cofactor.

Target	Sorbitol Dehydrogenase (SORD)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 211-239 amino acids from the Central region of human SORD.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q00796 (UniProt, ExPASy)
UniProt Secondary AC	B2R655, B7Z3A6, J3JZZ5, Q16682, Q9UMD6
UniProt Entry Name	DHSO_HUMAN
KEGG	hsa:6652
String	9606.ENSP00000267814
Molecular Weight	Calculated MW: 38.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Sorbitol Dehydrogenase (SORD)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue