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Sclerostin (SOST) Antibody
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Catalogue No: abx032756
Price:
US$326.25
(Size: 50 µl)
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Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Research Articles on Sclerostin (SOST)
| Target | Sclerostin (SOST) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 12-42 amino acids from the N-terminal region of human SOST. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9BQB4 (UniProt, ExPASy) |
| UniProt Secondary AC | Q495N9 |
| UniProt Entry Name | SOST_HUMAN |
| NCBI Accession | NP_079513.1 |
| String | 9606.ENSP00000301691 |
| Molecular Weight | Calculated MW: 24 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Cow SOST. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |