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Splicing Factor 3A Subunit 1 (SF3A1) Antibody
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Catalogue No: abx003281
Price:
US$203.00
(Size: 20 µl)
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SF3A1 Antibody is a Rabbit Polyclonal antibody against SF3A1. This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Research Articles on Splicing Factor 3A Subunit 1 (SF3A1)
| Target | Splicing Factor 3A Subunit 1 (SF3A1) |
| Clonality | Polyclonal |
| Reactivity | Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 715-785 of human SF3A1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q15459 (UniProt, ExPASy) |
| UniProt Secondary AC | E9PAW1 |
| UniProt Entry Name | SF3A1_HUMAN |
| GeneID | 10291 |
| KEGG | hsa:10291 |
| String | 9606.ENSP00000215793 |
| Molecular Weight | Calculated MW: 89 kDa Observed MW: 130 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |