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Sprouty RTK Signaling Antagonist 2 (SPRY2) Antibody
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Catalogue No: abx029506
Price:
US$326.25
(Size: 80 µl)
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This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq].
Research Articles on Sprouty RTK Signaling Antagonist 2 (SPRY2)
| Target | Sprouty RTK Signaling Antagonist 2 (SPRY2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 6-35 amino acids from the N-terminal region of human SPRY2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O43597 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R9J9, Q5T6Z7 |
| UniProt Entry Name | SPY2_HUMAN |
| Gene Symbol | SPRY2 |
| KEGG | hsa:10253 |
| String | 9606.ENSP00000366306 |
| Molecular Weight | Calculated MW: 34.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Monkey SPRY2. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |