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Sequestosome 1 (SQSTM1) Antibody
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Catalogue No: abx031570
Price:
US$326.25
(Size: 80 µl)
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SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination. This protein is involved in cell differentiation, apoptosis, immune response and regulation of K (+) channels. SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates. Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.
Research Articles on Sequestosome 1 (SQSTM1)
| Target | Sequestosome 1 (SQSTM1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/50 - 1/100, IF/ICC: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 317-346 amino acids from the C-terminal region of human SQSTM1 (p62). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13501 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NFN7, B2R661, B3KUW5, Q13446, Q9BUV7, Q9BVS6, Q9UEU1 |
| UniProt Entry Name | SQSTM_HUMAN |
| NCBI Accession | NP_001135770.1 NP_001135771.1 NP_003891.1 |
| KEGG | hsa:8878 |
| String | 9606.ENSP00000374455 |
| Molecular Weight | Calculated MW: 47.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat SQSTM1. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |