Signal Transducer And Activator of Transcription 3 (STAT3) Antibody

The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development.Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities.Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding.Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways.Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3a (86 kDa) and Stat3 beta (79 kDa) depend on cell type, ligand exposure or cell maturation stage.It is notable that Stat3 beta lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Target	Signal Transducer And Activator of Transcription 3 (STAT3)
Clonality	Monoclonal
Reactivity	Human, Mouse, Monkey
Tested Applications	ELISA, IHC, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human STAT3 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
GeneID	6774
Molecular Weight	88 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Signal Transducer And Activator of Transcription 3 (STAT3)

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