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Signal Transducer And Activator of Transcription 3 (STAT3) Antibody
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Catalogue No: abx029998
Price:
US$326.25
(Size: 80 µl)
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The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Research Articles on Signal Transducer And Activator of Transcription 3 (STAT3)
| Target | Signal Transducer And Activator of Transcription 3 (STAT3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IF/ICC: 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide from the C-terminal region of human STAT3, aa 711-743. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P40763 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K7B8, K7ENL3, O14916, Q9BW54 |
| UniProt Entry Name | STAT3_HUMAN |
| NCBI Accession | NP_003141.2 NP_644805.1 NP_998827.1 |
| KEGG | hsa:6774 |
| String | 9606.ENSP00000264657 |
| Molecular Weight | Calculated MW: 88.1 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |