Suppressor of Variegation 3-9 Homolog 2 (SUV39H2) Antibody

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.

Target	Suppressor of Variegation 3-9 Homolog 2 (SUV39H2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 367-395 amino acids from the C-terminal region of human SUV39H2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9H5I1 (UniProt, ExPASy)
UniProt Secondary AC	D3DRT4, Q5JSS4, Q5JSS5, Q6I9Y3, Q8ND06
UniProt Entry Name	SUV92_HUMAN
Gene Symbol	SUV39H2
String	9606.ENSP00000346997
Molecular Weight	Calculated MW: 46.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Monkey SUV39H2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Suppressor of Variegation 3-9 Homolog 2 (SUV39H2)

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