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Suppressor of Variegation 3-9 Homolog 2 (SUV39H2) Antibody
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Catalogue No: abx030784
Price:
US$326.25
(Size: 80 µl)
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Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.
Research Articles on Suppressor of Variegation 3-9 Homolog 2 (SUV39H2)
| Target | Suppressor of Variegation 3-9 Homolog 2 (SUV39H2) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 367-395 amino acids from the C-terminal region of human SUV39H2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9H5I1 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DRT4, Q5JSS4, Q5JSS5, Q6I9Y3, Q8ND06 |
| UniProt Entry Name | SUV92_HUMAN |
| Gene Symbol | SUV39H2 |
| String | 9606.ENSP00000346997 |
| Molecular Weight | Calculated MW: 46.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Monkey SUV39H2. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |