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T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody
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Catalogue No: abx240225
Price:
US$406.00
(Size: 100 µg)
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T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody is a mouse Monoclonal antibody for the detection of CD8. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.
Research Articles on T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A)
| Target | T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Mouse |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | CD8a molecule |
| Isotype | IgG1 |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P01732 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DT80, D6W5M8, Q13970, Q4ZG17 |
| UniProt Entry Name | CD8A_HUMAN |
| Gene Symbol | CD8A |
| GeneID | 925 |
| OMIM | 186910 |
| HGNC | 1706 |
| KEGG | hsa:925 |
| Ensembl | ENSG00000153563 |
| String | 9606.ENSP00000386559 |
| Molecular Weight | Observed MW: 30 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |