Microtubule-Associated Protein Tau (MAPT) Antibody

The microtubule-associated protein tau (MAPT) gene transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Target	Microtubule-Associated Protein Tau (MAPT)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat, Monkey
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/25, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 677-707 amino acids from the C-terminal region of human TAU.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P10636 (UniProt, ExPASy)
UniProt Secondary AC	P18518, Q14799, Q15549, Q15550, Q15551, Q1RMF6, Q53YB1, Q5CZI7, Q5XWF0, Q6QT54, Q9UDJ3, Q9UMH0, Q9UQ96
UniProt Entry Name	TAU_HUMAN
Gene Symbol	MAPT
GeneID	4137
OMIM	157140
HGNC	6893
KEGG	hsa:4137
Ensembl	ENSG00000186868
String	9606.ENSP00000340820
Molecular Weight	Calculated MW: 78.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Reacts with Human, Mouse, Rat and Cynomolgus Monkey MAPT. Predicted to react with Cow MAPT.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Microtubule-Associated Protein Tau (MAPT)

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