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TANK-Binding Kinase 1 (TBK) Antibody
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Catalogue No: abx033745
Price:
US$326.25
(Size: 80 µl)
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The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.
Research Articles on TANK-Binding Kinase 1 (TBK)
| Target | TANK-Binding Kinase 1 (TBK) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 150-181 amino acids from human TBK. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9UHD2 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K4S4, Q8IYV3, Q9NUJ5 |
| UniProt Entry Name | TBK1_HUMAN |
| NCBI Accession | NP_037386.1 |
| String | 9606.ENSP00000329967 |
| Molecular Weight | Calculated MW: 83.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Zebrafish and Xenopus TBK1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |