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TATA Box Binding Protein (TBP) Antibody
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Catalogue No: abx032930
Price:
US$326.25
(Size: 80 µl)
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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.
Research Articles on TATA Box Binding Protein (TBP)
| Target | TATA Box Binding Protein (TBP) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 210-239 amino acids from the Central region of human TBP. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P20226 (UniProt, ExPASy) |
| UniProt Secondary AC | B4E3B3, F5H869, Q16845, Q6IBM6, Q9UC02 |
| UniProt Entry Name | TBP_HUMAN |
| Gene Symbol | TBP |
| NCBI Accession | NP_001165556.1 NP_003185.1 |
| KEGG | hsa:6908 |
| String | 9606.ENSP00000375942 |
| Molecular Weight | Calculated MW: 37.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Cow, Monkey, Zebrafish and Xenopus TBP. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |