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Thymine DNA Glycosylase (TDG) Antibody
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Catalogue No: abx004405
Price:
US$217.50
(Size: 20 µl)
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TDG Antibody is a Rabbit Polyclonal antibody against TDG. The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
Research Articles on Thymine DNA Glycosylase (TDG)
| Target | Thymine DNA Glycosylase (TDG) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TDG. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13569 (UniProt, ExPASy) |
| UniProt Secondary AC | Q8IUZ6, Q8IZM3 |
| UniProt Entry Name | TDG_HUMAN |
| Gene Symbol | TDG |
| GeneID | 6996 |
| NCBI Accession | NP_003202.3 |
| KEGG | hsa:6996 |
| String | 9606.ENSP00000376611 |
| Molecular Weight | Calculated MW: 46 kDa Observed MW: 50 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |