Terminal Deoxyribonucleotidyltransferase (DNTT) Antibody

This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

Target	Terminal Deoxyribonucleotidyltransferase (DNTT)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 438-467 amino acids from the C-terminal region of human TdT.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P04053 (UniProt, ExPASy)
UniProt Secondary AC	Q53FH1, Q5W103, Q96E50
UniProt Entry Name	TDT_HUMAN
KEGG	hsa:1791
String	9606.ENSP00000360216
Molecular Weight	Calculated MW: 58.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse DNTT.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Terminal Deoxyribonucleotidyltransferase (DNTT)

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