Angiopoietin-1 Receptor / TIE2 (TEK) Antibody

The TIE2 receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TIE2 are associated with inherited venous malformations; the TIE2 signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TIE2 is closely related to the TIE receptor tyrosine kinase.

Target	Angiopoietin-1 Receptor / TIE2 (TEK)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 758-789 amino acids from the C-terminal region of human TEK (TIE2).
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q02763 (UniProt, ExPASy)
UniProt Secondary AC	A8K6W0, B4DH20, B4DHD3, D3DRK5, E7EWI2, Q5TCU2, Q8IV34
UniProt Entry Name	TIE2_HUMAN
NCBI Accession	NP_000450.2
KEGG	hsa:7010
String	9606.ENSP00000369375
Molecular Weight	Calculated MW: 126 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow TEK.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Angiopoietin-1 Receptor / TIE2 (TEK)

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