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Telomerase Reverse Transcriptase (TERT) Antibody
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Catalogue No: abx027803
Price:
US$326.25
(Size: 80 µl)
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Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.
Research Articles on Telomerase Reverse Transcriptase (TERT)
| Target | Telomerase Reverse Transcriptase (TERT) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/25, IF/ICC: 1/10 - 1/50, FCM: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1104-1132 amino acids from human TERT. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O14746 (UniProt, ExPASy) |
| UniProt Secondary AC | O14783, Q2XS35, Q8N6C3, Q8NG38, Q8NG46 |
| Gene Symbol | TERT |
| GeneID | 7015 |
| OMIM | 178500 |
| NCBI Accession | NP_001180305.1 NM_001193376.1 |
| HGNC | 11730 |
| KEGG | hsa:7015 |
| Ensembl | ENSG00000164362 |
| String | 9606.ENSP00000309572 |
| Molecular Weight | Calculated MW: 127 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |