Telomerase Reverse Transcriptase (TERT) Antibody

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.

Target	Telomerase Reverse Transcriptase (TERT)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/2000, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 627-656 amino acids from the Central region of human TERT.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O14746 (UniProt, ExPASy)
UniProt Secondary AC	O14783, Q2XS35, Q8N6C3, Q8NG38, Q8NG46
Gene Symbol	TERT
GeneID	7015
OMIM	178500
NCBI Accession	NP_001180305.1 NM_001193376.1
HGNC	11730
KEGG	hsa:7015
Ensembl	ENSG00000164362
String	9606.ENSP00000309572
Molecular Weight	Calculated MW: 127 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Telomerase Reverse Transcriptase (TERT)

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