Transcription Factor Binding To IGHM Enhancer 3 (TFE3) Antibody

REQUEST MORE INFO
Catalogue No: abx030197
Price: US$326.25
(Size: 80 µl)
Reviews: 0 Publications and Reviews
(0 Publications and Reviews)

Click on the image to see the image legend

Transcription Factor Binding To IGHM Enhancer 3 (TFE3) Antibody
Transcription Factor Binding To IGHM Enhancer 3 (TFE3) Antibody Transcription Factor Binding To IGHM Enhancer 3 (TFE3) Antibody Transcription Factor Binding To IGHM Enhancer 3 (TFE3) Antibody

Available Options

* Size:


Add to Shopping Cart Buy It Now GET A QUOTE

Documents

Datasheet SDS
The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1) ; it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb) TFE3 and ASPL-TFE3.

Target Transcription Factor Binding To IGHM Enhancer 3 (TFE3)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications ELISA, WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TFE3.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P19532 (UniProt, ExPASy)
UniProt Secondary AC A8MZL6, Q5JU74, Q92757, Q92758, Q99964
UniProt Entry Name TFE3_HUMAN
Gene Symbol TFE3
KEGG hsa:7030
String 9606.ENSP00000314129
Molecular Weight Calculated MW: 61.5 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Transcription Factor Binding To IGHM Enhancer 3 (TFE3)
Tags:
(Click to show)