Transforming Growth Factor Beta-1 (TGFB1) Antibody

TGF beta (transforming growth factor beta), with 390-amino acid protein (about 43 kDa), is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. In mammals, three isoforms of TGF beta, that is, beta 1, beta 2,and beta 3,are known. TGF beta is one of numerous inhibitory factors produced by cancer cells that regulate antitumor immunity. TGF beta 1 takes part in the local response in the course of primary lung cancer and TGF beta 1 is thought to be implicated in breast cancer progression.TGF beta 1 also plays a critical role in the downregulation of microglial responses minimizing brain inflammation and thus avoiding exacerbation of brain damage.

Target	Transforming Growth Factor Beta-1 (TGFB1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of TGF beta1 expressed in E. coli.
Isotype	IgG2a
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P01137 (UniProt, ExPASy)
UniProt Secondary AC	A8K792, Q9UCG4
UniProt Entry Name	TGFB1_HUMAN
Gene Symbol	TGFB1
GeneID	7040
OMIM	131300
HGNC	11766
KEGG	hsa:7040
Ensembl	ENSG00000105329
String	9606.ENSP00000221930
Molecular Weight	45 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Transforming Growth Factor Beta-1 (TGFB1)

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