Transforming Growth Factor Beta 1 (TGFb1) Antibody

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

Target	Transforming Growth Factor Beta 1 (TGFb1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human TGFb1 (AA: 62-195) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P01137 (UniProt, ExPASy)
UniProt Secondary AC	A8K792, Q9UCG4
UniProt Entry Name	TGFB1_HUMAN
Gene Symbol	TGFB1
GeneID	7040
OMIM	131300
HGNC	11766
KEGG	hsa:7040
Ensembl	ENSG00000105329
String	9606.ENSP00000221930
Molecular Weight	44.3 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Transforming Growth Factor Beta 1 (TGFb1)

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