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TGFB Induced Factor Homeobox 1 (TGIF1) Antibody
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Catalogue No: abx028149
Price:
US$326.25
(Size: 80 µl)
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The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.
Research Articles on TGFB Induced Factor Homeobox 1 (TGIF1)
| Target | TGFB Induced Factor Homeobox 1 (TGIF1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human TGIF1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q15583 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NE42, A6NLU7, F8VZB6, Q6ICR0, Q8N5X9, Q9NRS0 |
| UniProt Entry Name | TGIF1_HUMAN |
| KEGG | hsa:7050 |
| String | 9606.ENSP00000327959 |
| Molecular Weight | Calculated MW: 43 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |