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THO Complex 6 (THOC6) Antibody
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Catalogue No: abx030427
Price:
US$326.25
(Size: 80 µl)
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Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4.
Research Articles on THO Complex 6 (THOC6)
| Target | THO Complex 6 (THOC6) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 96-123 amino acids from the Central region of human THOC6. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q86W42 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RA85, Q8NBR1, Q9BTV9 |
| UniProt Entry Name | THOC6_HUMAN |
| Gene Symbol | THOC6 |
| KEGG | hsa:79228 |
| String | 9606.ENSP00000326531 |
| Molecular Weight | Calculated MW: 37.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat THOC6. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |