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Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody
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Catalogue No: abx034891
Price:
US$326.25
(Size: 80 µl)
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Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Research Articles on Toll Like Receptor Adaptor Molecule 1 (TICAM1)
| Target | Toll Like Receptor Adaptor Molecule 1 (TICAM1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 115-143 amino acids from the N-terminal region of human TICAM1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q8IUC6 (UniProt, ExPASy) |
| UniProt Secondary AC | B3Y691, O75532, Q86XP8, Q96GA0 |
| UniProt Entry Name | TCAM1_HUMAN |
| Gene Symbol | TICAM1 |
| NCBI Accession | NP_891549.1 |
| Molecular Weight | Calculated MW: 76.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |