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Toll Like Receptor 2 (TLR2) Antibody
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Catalogue No: abx147259
Price:
US$406.00
(Size: 100 µg)
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Toll Like Receptor 2 (TLR2) Antibody is a Rabbit Polyclonal antibody for the detection of TLR2. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.
Research Articles on Toll Like Receptor 2 (TLR2)
| Target | Toll Like Receptor 2 (TLR2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Toll-like receptor 2 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | O60603 (UniProt, ExPASy) |
| UniProt Secondary AC | B3Y612, D1CS45, D1CS48, D1CS49, O15454, Q8NI00 |
| Gene Symbol | TLR2 |
| GeneID | 7097 |
| OMIM | 246300 |
| NCBI Accession | NP_003255.2 |
| HGNC | 11848 |
| KEGG | hsa:7097 |
| Ensembl | ENSG00000137462 |
| String | 9606.ENSP00000260010 |
| Molecular Weight | Observed MW: 105 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |