Toll Like Receptor 2 (TLR2) Antibody

Toll Like Receptor 2 (TLR2) Antibody is a Rabbit Polyclonal antibody for the detection of TLR2.

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.

Target	Toll Like Receptor 2 (TLR2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Toll-like receptor 2
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	O60603 (UniProt, ExPASy)
UniProt Secondary AC	B3Y612, D1CS45, D1CS48, D1CS49, O15454, Q8NI00
Gene Symbol	TLR2
GeneID	7097
OMIM	246300
NCBI Accession	NP_003255.2
HGNC	11848
KEGG	hsa:7097
Ensembl	ENSG00000137462
String	9606.ENSP00000260010
Molecular Weight	Observed MW: 105 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Toll Like Receptor 2 (TLR2)

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