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Toll Like Receptor 2 (TLR2) Antibody
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Catalogue No: abx028479
Price:
US$326.25
(Size: 80 µl)
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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
Research Articles on Toll Like Receptor 2 (TLR2)
| Target | Toll Like Receptor 2 (TLR2) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 212-242 amino acids from the N-terminal region of human TLR2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O60603 (UniProt, ExPASy) |
| UniProt Secondary AC | B3Y612, D1CS45, D1CS48, D1CS49, O15454, Q8NI00 |
| Gene Symbol | TLR2 |
| GeneID | 7097 |
| OMIM | 246300 |
| NCBI Accession | NP_003255.2 |
| HGNC | 11848 |
| KEGG | hsa:7097 |
| Ensembl | ENSG00000137462 |
| String | 9606.ENSP00000260010 |
| Molecular Weight | Calculated MW: 89.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Monkey TLR2. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |