Transmembrane Emp24 Domain-Containing Protein 10 (TMED10) Antibody

TMED10 Antibody is a Rabbit Polyclonal antibody against TMED10. This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.

Target	Transmembrane Emp24 Domain-Containing Protein 10 (TMED10)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 35-190 of human TMED10.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49755 (UniProt, ExPASy)
UniProt Secondary AC	B2R605, Q15602, Q16536, Q86TC2, Q86TS5
UniProt Entry Name	TMEDA_HUMAN
Gene Symbol	TMED10
GeneID	10972
NCBI Accession	NP_006818.3
KEGG	hsa:10972
String	9606.ENSP00000303145
Molecular Weight	Calculated MW: 25 kDa Observed MW: 21 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Transmembrane Emp24 Domain-Containing Protein 10 (TMED10)

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