Transmembrane Protein 43 (TMEM43) Antibody

This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.

Target	Transmembrane Protein 43 (TMEM43)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 195-223 amino acids from the Central region of human TMEM43.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9BTV4 (UniProt, ExPASy)
UniProt Secondary AC	Q7L4N5, Q8NC30, Q96A63, Q96F19, Q96JX0, Q9H076
UniProt Entry Name	TMM43_HUMAN
Gene Symbol	TMEM43
String	9606.ENSP00000303992
Molecular Weight	Calculated MW: 44.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat TMEM43.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Transmembrane Protein 43 (TMEM43)

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