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Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10) Antibody
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Catalogue No: abx001750
Price:
US$203.00
(Size: 20 µl)
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TNFSF10 Antibody is a Rabbit Polyclonal antibody against TNFSF10. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Articles on Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10)
| Target | Tumor Necrosis Factor Ligand Superfamily Member 10 / TRAIL (TNFSF10) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human TNFSF10. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P50591 (UniProt, ExPASy) |
| UniProt Secondary AC | A1Y9B3 |
| UniProt Entry Name | TNF10_HUMAN |
| Gene Symbol | TNFSF10 |
| GeneID | 8743 |
| NCBI Accession | NP_003801.1 |
| KEGG | hsa:8743 |
| String | 9606.ENSP00000241261 |
| Molecular Weight | Calculated MW: 33 kDa Observed MW: 28 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | 1.33 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |