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Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) Antibody
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Catalogue No: abx001988
Price:
US$348.00
(Size: 60 µl)
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TNFSF11 Antibody is a Rabbit Polyclonal antibody against TNFSF11. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Research Articles on Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11)
| Target | Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human RANKL |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O14788 (UniProt, ExPASy) |
| UniProt Secondary AC | O14723, Q96Q17, Q9P2Q3 |
| Gene Symbol | TNFSF11 |
| GeneID | 8600 |
| NCBI Accession | NP_003692.1 |
| Molecular Weight | Calculated MW: 27 kDa/30 kDa/35 kDa Observed MW: 31 kDa/45 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |