Troponin I, Cardiac Muscle (TNINI3) Antibody

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). This antibody is supplied as crude ascites.

Target	Troponin I, Cardiac Muscle (TNINI3)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/8000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 52-79 amino acids from human TNINI3.
Isotype	IgM
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P19429 (UniProt, ExPASy)
UniProt Entry Name	TNNI3_HUMAN
KEGG	hsa:7137
String	9606.ENSP00000341838
Molecular Weight	Calculated MW: 24 kDa
Buffer	Ascites containing 0.09% sodium azide.
Specificity	Predicted to react with Cow and Horse TNNI3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Troponin I, Cardiac Muscle (TNINI3)

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