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Tyrosine Kinase, Non Receptor 2 / ACK1 (TNK2) Antibody
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Catalogue No: abx001966
Price:
US$203.00
(Size: 20 µl)
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TNK2 Antibody is a Rabbit Polyclonal antibody against TNK2. This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
Research Articles on Tyrosine Kinase, Non Receptor 2 / ACK1 (TNK2)
| Target | Tyrosine Kinase, Non Receptor 2 / ACK1 (TNK2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 920-1038 of human TNK2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q07912 (UniProt, ExPASy) |
| UniProt Secondary AC | Q6ZMQ0, Q8N6U7, Q96H59 |
| UniProt Entry Name | ACK1_HUMAN |
| Gene Symbol | TNK2 |
| GeneID | 10188 |
| NCBI Accession | NP_005772.3 |
| KEGG | hsa:10188 |
| String | 9606.ENSP00000371341 |
| Molecular Weight | Calculated MW: 115 kDa Observed MW: 115 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |