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Troponin I, Slow Skeletal Muscle (TNNI1) Antibody
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Catalogue No: abx003074
Price:
US$203.00
(Size: 20 µl)
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TNNI1 Antibody is a Rabbit Polyclonal antibody against TNNI1. Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
Research Articles on Troponin I, Slow Skeletal Muscle (TNNI1)
| Target | Troponin I, Slow Skeletal Muscle (TNNI1) |
| Clonality | Polyclonal |
| Reactivity | Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human Troponin I1/TnI1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P19237 (UniProt, ExPASy) |
| UniProt Entry Name | TNNI1_HUMAN |
| Gene Symbol | TNNI1 |
| GeneID | 7135 |
| NCBI Accession | NP_003272.3 |
| KEGG | hsa:7135 |
| String | 9606.ENSP00000354488 |
| Molecular Weight | Calculated MW: 22 kDa Observed MW: 22 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |