Tryptophan Hydroxylase 2 (TPH2) Antibody

TPH2 Antibody is a Rabbit Polyclonal antibody against TPH2. This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Target	Tryptophan Hydroxylase 2 (TPH2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1-170 of human TPH2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q8IWU9 (UniProt, ExPASy)
UniProt Secondary AC	A6NGA4, Q14CB0
UniProt Entry Name	TPH2_HUMAN
Gene Symbol	TPH2
GeneID	121278
NCBI Accession	NP_775489.2
KEGG	hsa:121278
String	9606.ENSP00000329093
Molecular Weight	Calculated MW: 56 kDa Observed MW: 56/52 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tryptophan Hydroxylase 2 (TPH2)

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