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Tropomyosin 1 (TPM1) Antibody
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Catalogue No: abx117045
Price:
US$522.00
(Size: 100 µl)
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TPM1 Antibody is a Rabbit Polyclonal antibody against TPM1. Tropomyosin-1 (TPM1) belongs to the high molecular weight members of tropomyosin familyThe protein exists in an alpha-helical coiled-coil conformation and binds multiple acting monomers in a tight manner to stabilize and regulate the actin filamentTropomyosins fullfill functions in muscle and non-muscle cellsIn muscle cells, tropomyosins associate with the troponin complex and play a central role in the calcium-dependent regulation of striated muscle contraction in vertebRatesIn non-muscle cells, tropomyosins are implicated in the formation and stabilization of cytoskeletal actin filaments to ensure normal cellular processesMutations of tropomysin-1 have been reported as a cause of dilated cardiac myopathiesTropomyosin-1 also functions as a tumor suppressor, and many malignant tumors demonstRate downregulation of tropomyosin-1 expressionTropomyosin-1 is phosphorylated at Ser283 through the Erk/DAPK pathway, which promotes stress fiber formation in response to oxidative stress.
Research Articles on Tropomyosin 1 (TPM1)
| Target | Tropomyosin 1 (TPM1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein of human TPM1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P09493 (UniProt, ExPASy) |
| UniProt Entry Name | TPM1_HUMAN |
| Gene Symbol | TPM1 |
| GeneID | 7168 |
| KEGG | hsa:7168 |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |