Tryptase Alpha/Beta-1 (TPSAB1) Antibody

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Catalogue No: abx001641
Price: US$348.00
(Size: 60 µl)
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Immunohistochemistry of paraffin-embedded Human appendix using TPSAB1 Antibody (1/100 dilution, 40x lens).
Tryptase Alpha/Beta-1 (TPSAB1) Antibody

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TPSAB1 Antibody is a Rabbit Polyclonal antibody against TPSAB1. Tryptase Alpha/Beta-1s comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptase Alpha/Beta-1s are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several Tryptase Alpha/Beta-1 genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of Tryptase Alpha/Beta-1s but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta Tryptase Alpha/Beta-1s appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha Tryptase Alpha/Beta-1s predominate. Tryptase Alpha/Beta-1s have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

Target Tryptase Alpha/Beta-1 (TPSAB1)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications IHC
Host Rabbit
Recommended dilutions IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide corresponding to human TPSAB1
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q15661 (UniProt, ExPASy)
UniProt Entry Name TRYB1_HUMAN
Gene Symbol TPSAB1
GeneID 7177
NCBI Accession NP_003285.2
KEGG hsa:7177
String 9606.ENSP00000343577
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration 1 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Tryptase Alpha/Beta-1 (TPSAB1)
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