TNF Receptor Associated Factor 2 (TRAF2) Antibody

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Target	TNF Receptor Associated Factor 2 (TRAF2)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC
Host	Mouse
Recommended dilutions	WB: 1/100 - 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Human TRAF2 recombinant protein.
Isotype	IgG1 Kappa
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q12933 (UniProt, ExPASy)
UniProt Secondary AC	A8K107, B4DPJ7, Q7Z337, Q96NT2
UniProt Entry Name	TRAF2_HUMAN
KEGG	hsa:7186
String	9606.ENSP00000247668
Molecular Weight	Calculated MW: 55.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on TNF Receptor Associated Factor 2 (TRAF2)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue