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TNF Receptor Associated Factor 2 (TRAF2) Antibody
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Catalogue No: abx000916
Price:
US$217.50
(Size: 20 µl)
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TRAF2 Antibody is a Rabbit Polyclonal antibody against TRAF2. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
Research Articles on TNF Receptor Associated Factor 2 (TRAF2)
| Target | TNF Receptor Associated Factor 2 (TRAF2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IP: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human TRAF2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q12933 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K107, B4DPJ7, Q7Z337, Q96NT2 |
| UniProt Entry Name | TRAF2_HUMAN |
| Gene Symbol | TRAF2 |
| GeneID | 7186 |
| NCBI Accession | NP_066961.2 |
| KEGG | hsa:7186 |
| String | 9606.ENSP00000247668 |
| Molecular Weight | Calculated MW: 56 kDa Observed MW: 54 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |