Thyrotropin-Releasing Hormone Receptor (TRHR) Antibody

Thyrotropin-releasing hormone (TRH; MIM 275120), a small neuropeptide, is widely distributed throughout the central and peripheral nervous system as well as in extraneural tissues. The peptide is synthesized in the hypothalamus and transported by the portal vascular system to the anterior pituitary where it acts on thyrotropic and lactotropic cells to promote secretion of TSH and prolactin, respectively. Thyrotropin-releasing hormone receptor is a G protein-coupled receptor that activates the inositol phospholipid-calcium-protein kinase C transduction pathway upon the binding of TRH. The TRHR gene is expressed in the thyrotrope cells of the anterior pituitary.

Target	Thyrotropin-Releasing Hormone Receptor (TRHR)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 209-238 amino acids from the Central region of human TRHR.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P34981 (UniProt, ExPASy)
UniProt Secondary AC	Q2M339
UniProt Entry Name	TRFR_HUMAN
Gene Symbol	TRHR
KEGG	hsa:7201
String	9606.ENSP00000430711
Molecular Weight	Calculated MW: 45.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat TRHR.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Thyrotropin-Releasing Hormone Receptor (TRHR)

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