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GP145-TrkC (TRKC) Antibody
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Catalogue No: abx033618
Price:
US$326.25
(Size: 80 µl)
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TRKC, a member of the insuline receptor subfamily of Tyr protein kinases, is a receptor for neurotrophin-3 (NT-3). Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
Research Articles on GP145-TrkC (TRKC)
| Target | GP145-TrkC (TRKC) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 31-61 amino acids from the N-terminal region of human TRKC. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q16288 (UniProt, ExPASy) |
| UniProt Secondary AC | B7Z4C5, E9PG56, H0YND1, O75682, Q12827, Q16289 |
| UniProt Entry Name | NTRK3_HUMAN |
| KEGG | hsa:4916 |
| String | 9606.ENSP00000354207 |
| Molecular Weight | Calculated MW: 94.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Pig and Monkey NTRK3. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |