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Hamartin (TSC1) Antibody
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Catalogue No: abx034674
Price:
US$326.25
(Size: 80 µl)
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In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
Research Articles on Hamartin (TSC1)
| Target | Hamartin (TSC1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 395-424 amino acids from the Central region of human TSC1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q92574 (UniProt, ExPASy) |
| UniProt Secondary AC | B7Z897, Q5VVN5 |
| UniProt Entry Name | TSC1_HUMAN |
| KEGG | hsa:7248 |
| String | 9606.ENSP00000298552 |
| Molecular Weight | Calculated MW: 130 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |