+44 (0) 1223 755950
+1 832 327 7413
TSC1 (pS505) Antibody
REQUEST MORE INFO
Catalogue No: abx031998
Price:
US$326.25
(Size: 80 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.
Research Articles on TSC1 (pS505)
| Target | TSC1 (pS505) |
| Clonality | Polyclonal |
| Target Modification | Ser505 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, DB |
| Host | Rabbit |
| Recommended dilutions | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S505 of human TSC1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q92574 (UniProt, ExPASy) |
| UniProt Secondary AC | B7Z897, Q5VVN5 |
| UniProt Entry Name | TSC1_HUMAN |
| KEGG | hsa:7248 |
| String | 9606.ENSP00000298552 |
| Molecular Weight | Calculated MW: 130 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse TSC1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |