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Dual Specificity Protein Kinase TTK (TTK) Antibody
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Catalogue No: abx029350
Price:
US$326.25
(Size: 80 µl)
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This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
Research Articles on Dual Specificity Protein Kinase TTK (TTK)
| Target | Dual Specificity Protein Kinase TTK (TTK) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 6-35 amino acids from the N-terminal region of human TTK. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P33981 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K8U5, B2RDW2, E1P543, Q15272, Q5TCS0, Q9BW51, Q9NTM0 |
| UniProt Entry Name | TTK_HUMAN |
| Gene Symbol | TTK |
| KEGG | hsa:7272 |
| String | 9606.ENSP00000358813 |
| Molecular Weight | Calculated MW: 97.1 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Monkey TTK. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |