Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein (TRADD) Antibody

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Catalogue No: abx012271
Price: US$406.00
(Size: 100 µg)

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Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein (TRADD) Antibody is a Rabbit Polyclonal antibody for the detection of TRADD.

The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Target Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein (TRADD)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions WB: 1/200 - 1/2000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen TNFRSF1A-associated via death domain
Isotype IgG
Form Liquid
Purity ≥ 95% (SDS-PAGE)
Purification Purified by immunogen affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity 12 months.
UniProt Primary AC Q15628 (UniProt, ExPASy)
UniProt Secondary AC B2RDS3, B3KQZ9, Q52NZ1
UniProt Entry Name TRADD_HUMAN
Gene Symbol TRADD
GeneID 8717
OMIM 603500
HGNC 12030
KEGG hsa:8717
Ensembl ENSG00000102871
String 9606.ENSP00000341268
Molecular Weight Observed MW: 34 kDa, 27 kDa
Buffer PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration 2 mg/ml
Availability Shipped within 5-12 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein (TRADD)
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